Principal Software Engineer
Baylor Genetics· Biotechnology· Oct 23, 2026 · 5d ago
United States
Remote
Full-time
Principal
$141K–$216K est.
10+ years exp
Job description
KEY RESPONSIBILITES
· Lead the architecture, design, and development of complex software systems and platforms
· Define and champion engineering standards, best practices, and long-term technical roadmaps
· Collaborate with cross-functional teams to translate business needs into scalable, secure, and maintainable solutions
· Conduct deep technical reviews, guide system design discussions, and ensure architectural consistency across teams
· Mentor and coach engineers, fostering a culture of technical excellence and continuous learning
· Drive root-cause analysis and resolution of complex technical issues, ensuring system reliability and data integrity
· Evaluate emerging technologies and guide strategic adoption where appropriate
· Partner with product, laboratory, and bioinformatics teams to optimize workflows and enhance operational efficiency
· Ensure compliance with security, privacy, and regulatory requirements across all software systems
· Contribute to innovation initiatives that advance Baylor Genetics’ digital capabilities and competitive advantage
· Perform other duties as assigned to support team and organizational objectives.
· Comply with all company policies, procedures, and applicable regulatory requirements.
QUALIFICATIONS
Required
· B.S. in Computer Science or related field required
· 10+ years of professional software engineering experience, including significant experience in large-scale or complex systems
· Expert-level proficiency with C# and .NET (e.g., .NET Core / .NET 6+)
· Extensive experience architecting and building React + TypeScript applications
· Deep expertise with relational databases such as MS SQL Server, PostgreSQL, or MySQL, including schema design, performance tuning, and data modeling
· Proven experience designing, implementing, and governing RESTful APIs and distributed systems
· Strong background in software architecture, system design, and engineering best practices
· Demonstrated experience leading technical initiatives, mentoring engineers, and influencing cross-functional decision-making
· Strong understanding of DevOps principles, CI/CD pipelines, and cloud-native architectures
· Excellent analytical and problem-solving skills with the ability to navigate ambiguity and complexity
· Equivalent combination of education and experience may be considered.
Preferred:
· M.S. or higher preferred in Computer Science or related field
· Experience in healthcare, clinical diagnostics, genomics, or NGS environments
· Familiarity with laboratory workflows, LIMS systems, or clinical reportingplatforms
· Experience working in regulated environments (CLIA, CAP, HIPAA)
· Background in designing secure, compliant, and audit-ready systems
· Experience with high-performance or data-intensive applications, including optimization and scalability strategies
COMPETENCIES
· A strategic technical leader who can define long-term architectural direction
· Strong ownership mindset with the ability to drive initiatives from concept to production
· Exceptional communication skills, capable of translating complex technical concepts for diverse audiences
· A collaborative partner who elevates team performance and mentors engineers at all levels
· Sound judgment balancing innovation, speed, quality, and regulatory requirements
· Passion for building systems that directly support clinical decision-making and patient outcomes
PHYSICAL DEMANDS AND WORK ENVIRONMENT
· Location: Remote
EEO Statement:
Baylor Genetics is proud to be an equal opportunity employer committed to fostering an inclusive and diverse workplace. We welcome and encourage applicants from all backgrounds to apply. We do not discriminate on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, age, veteran status, disability, genetic information, pregnancy, childbirth, or any other status protected by applicable federal, state, or local law. If you need an accommodation during the application process, please contact our Human Resources team.
Note to Recruiters:
We value building direct relationships with our candidates and prefer to manage our hiring process internally. While we occasionally partner with select recruitment agencies for specialized roles, we do not accept unsolicited resumes from recruiters or agencies without a written agreement executed by the authorized signatory for Baylor Genetics ("Agreement"). Any resumes submitted to Baylor Genetics in the absence of an Agreement executed by Baylor Genetics' authorized signatory, will be considered the property of Baylor Genetics, and Baylor Genetics will not be obligated to pay any associated recruitment fees.
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