Sr. Principal Engineer - Automation Engineering – Small Molecule, Lilly Medicine Foundry
Eli Lilly and Company· startup· Pharmaceuticals· Sep 11, 2026 · 2mo ago
US, Lebanon IN
In office
Full-time
Principal
$68K–$174K
8+ years exp
Job description
At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
Organization and Position Overview
Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development. The first-ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact.
The Sr. Principal Engineer - Automation Engineering will work as a member of the Automation Engineering Department at Eli Lilly, Foundry. The Sr. Principal engineer will provide automation support for one or more operating areas across site and/or for capital projects. Process Automation is core to delivering a right first time facility start up and continued support of ongoing manufacturing operations into the future.
The Sr. Principal Engineer is also responsible for the productivity and mentorship of the employees with the purpose of ensuring that reliable and complaint-controlled applications and systems are used in the manufacturing at Foundry. Additionally, the Sr. Principal Engineer, as a key technical expert partners to influence and implement within the process control organization and across functional disciplines to support the process control technical agenda, business plan priorities, and compliance objectives.
In the project delivery phase and startup phase of the project (startup expected 2025 to 2028), automation engineering roles will be fluid and dynamic as we endeavor to support the project delivery, build a new organization, develop and implement the necessary systems and business processes required to support GMP operations, and build the site culture. This will require significant collaboration, creativity and resilience as the site grows to a full scale GMP manufacturing through start up.
Responsibilities
Key Objectives/Deliverables:
Technical Leadership
Mentor process control team, including design, controls philosophy, implementation and commissioning
Process control work implementation and coordination
Review and monitor financial performance; commit to meeting targets
Develop and implement the Automation Engineering Project Plan.
Operational Excellence
Technically lead and oversee the work of Site Area leads and System Integrator including Functional Requirements, Design Specifications, DCS Application Software, Test Specifications.
Lead/Participate in design reviews and DeltaV application software reviews, attend equipment and software FATs
Lead a team of automation engineers supporting commissioning
Provide periodic status updates to Project Management
Devise functional requirements and process control strategies for control systems in collaboration with Process Engineering
DCS and SCADA software design, coding/configuration and testing (sequence logic, graphics, batch software etc.)
Perform automation engineering activities including design, tuning and troubleshooting of control loops
Implement and support electronic systems (such as plant historians, applications and software integration) used to capture process automation related production data
Maintain the validated state of the site control systems in line with Lilly quality standards including the development and execution of validation strategies and associated documentation
Automation support for capital projects including new product introductions
Promoting the use of automation to improve productivity, operational efficiency and compliance
Developing a ‘network’ of corporate contacts and leveraging corporate expertise when needed
Organizational Capability
In coordination with automation and compliance consultants, set and reinforce standards for appropriate rigor in automation work products.
Demonstrated initiative, good planning and organizational skills, ability to prioritize tasks, commitment to task completion and timelines.
Possess a keen technical curiosity and has demonstrated strong problem-solving skills and a desire for continuous improvement
Demonstrated ability to influence peers and business partners
Good written and verbal communication skills for both technical and non-technical audiences
Support the flow leadership in running the plant, including participation in management sub-teams.
Knowledge of GMP, regulatory requirements, computer system validation
Basic Requirements:
Minimum B.S. in Engineering or related discipline and 8 years working experience in Automation Engineering, preferably in Small Molecule or Biologics.
Experience in design, development, commissioning and qualification of highly automated greenfield or brownfield manufacturing sites utilizing SCADA, DCS, PLC and MES systems (DeltaV, Rockwell, Syncade, etc).
Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1.
Additional Preferences:
Experience working with kilo or high potency labs highly preferred. Experience with peptides, oligonucleotides, or ADC’s (antibody drug conjugates) preferred
Experience in facilitating and driving decision-making at an organizational level.
Ability to instill teamwork within the department and demonstrate key interpersonal skills.
Proficient in DeltaV Distributed Control System, Rockwell Allen-Bradley PLC, and batch process automation.
Experience with ISA-88 Batch-control standard models, terminology, recipes and procedural elements.
Prior work with 21 CFR Part 11 and cGMP regulatory requirements, including computer system validation.
Proven ability to influence peers and business partners, including influencing without authority, and to facilitate decision-making at an organizational level.
Other Information:
Initial location at Parkwood West, Indianapolis.
Permanent location at the new Lilly Medicines Foundry in Lebanon, Indiana.
Travel Percentage: Some travel required to support equipment/software Factory Acceptance Tests (FATs), typically at vendor or system integrator sites.
Act as an escalation resource for complex operational and process inquiries, delivering advanced support and issue resolution as business needs arise. Need-based off-hour support may be needed.
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
#WeAreLilly
Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form ( careers.lilly.com ) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.
Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.
Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).
Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
$67,500 - $173,800
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
#WeAreLilly
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Benefits
Benefits detected in the listing.
Dental
Vision
401(K)