Job description

AWS Applied AI Solutions (AAIS) is building toward a future where every business innovates with Amazon AI teammates. To get there, we build AI solutions that improve human capabilities and transform entire business functions. We create end-to-end products that surprise and delight out-of-the-box, making complex things easy and hard things possible, with no cloud experience required. We start with customers who embrace the future and build bridges to meet the rest where they are. We pursue ambitious opportunities with conviction, and we are looking for builders who share that mindset. The Team Join the next science revolution at AWS Life Sciences Applied AI Solutions where you'll work alongside world-class scientists to build AI that transforms how therapeutics are discovered, developed, and brought to patients. We're out to revolutionize how medicines are discovered, developed, and brought to patients powered by a new generation of AI. Our team tackles some of the hardest open problems at the intersection of frontier AI and life sciences. We apply biological foundation models large language models and agentic reasoning systems to life sciences problems then put them into the hands of customers as applications and managed services they can fine-tune tailor and deploy on their own data. The science challenges are deep: how do you design agentic systems that reason correctly over complex biological regulatory and clinical logic? How do you enable customers to tailor foundation models to their proprietary data and get better outputs with less effort? How do you adapt models to reason faithfully in high-stakes scientific and regulatory domains? Today we're focused on two areas. In clinical trials we're building AI that automates and optimizes regulatory and clinical development workflows. In drug design our products (including Amazon Bio Discovery) accelerate discovery by giving bench scientists AI-guided protein engineering and antibody design capabilities. We combine frontier research with production-scale delivery to put breakthrough science into the hands of customers solving humanity's hardest problems. We value scientific rigor encourage publication and support conference participation. If you want to do research that ships this is the team. The Role We are seeking an Applied Scientist to build the models and methods behind our life sciences AI products with a primary focus on clinical trial operations and agentic reasoning. You will design train and evaluate systems that reason over complex clinical and operational logic and ship them into products customers use directly. You will work closely with senior and principal scientists on well-scoped research problems own your results end to end and see your work reach production. This role combines expertise in LLM reasoning and agentic AI with applied impact in life sciences. You will work on how large language models reason plan and act in complex scientific domains while applying domain knowledge to ensure models produce scientifically valid outputs. The problems span multiple fronts: • How do you build LLM-based agentic systems that correctly reason over clinical protocols regulatory standards and complex multi-step operational workflows? • How do you evaluate agent reliability and faithfulness rigorously enough to trust in high-stakes clinical settings? • How do you develop model customization methods (fine-tuning retrieval augmentation domain adaptation) that let customers get strong results from foundation models on their own data? You will focus on clinical trial operations (agentic automation structured reasoning evaluation domain adaptation) with opportunities to contribute across drug discovery (protein engineering antibody design) as the portfolio grows. You will own end-to-end scientific solutions from research through production and your work will directly shape the tools that scientists use daily. Key job responsibilities • Design train fine-tune and evaluate LLM-based agentic systems that reason over clinical protocols regulatory standards and operational workflows • Build rigorous evaluation harnesses and benchmarks to measure agent reliability faithfulness and failure modes in high-stakes domains • Develop model customization methods (fine-tuning RLHF retrieval augmentation domain adaptation) that help customers get better outputs on their own data with less effort • Contribute to graph-based and causal modeling approaches for clinical trial operations • Partner with Life Sciences domain experts product and engineering to translate scientific challenges into shipped capabilities • Own experiments end to end: problem framing implementation evaluation iteration and hand-off to production • Publish at top-tier venues where the work supports it • Contribute to drug discovery efforts (protein engineering antibody design) as opportunities arise A day in the life • Design and run an experiment to validate a new agentic reasoning or fine-tuning method then ship it as a capability customers can use • Diagnose why a model is failing on a new class of inputs and implement a fix to unblock a delivery milestone • Build or extend an evaluation benchmark to measure how faithfully an agent reasons over clinical logic • Meet with domain experts to scope what the next model release needs to do • Review results with a senior scientist sharpen the approach and get it over the finish line • Prototype a new idea that could become the next capability in the product About the team Amazon values diverse experiences. Even if you do not meet all of the preferred qualifications and skills listed in the job description, we encourage candidates to apply. If your career is just starting, hasn't followed a traditional path, or includes alternative experiences, don't let it stop you from applying. Amazon Web Services (AWS) is the world's most comprehensive and broadly adopted cloud platform. We pioneered cloud computing and never stopped innovating — that's why customers from the most successful startups to Global 500 companies trust our robust suite of products and services to power their businesses. We value work-life harmony. Achieving success at work should never come at the expense of sacrifices at home, which is why flexible work hours and arrangements are part of our culture. When we feel supported in the workplace and at home, there's nothing we can't achieve in the cloud. Here at AWS, it's in our nature to learn and be curious. Our employee-led affinity groups foster a culture of inclusion that empower us to be proud of our differences. Ongoing events and learning experiences, including our Conversations on Race and Ethnicity and AmazeCon conferences, inspire us to never stop embracing our uniqueness. We're continuously raising our performance bar as we strive to become Earth's Best Employer. That's why you'll find endless knowledge-sharing, mentorship and other career-advancing resources here to help you develop into a better-rounded professional. - Master's degree or above in a relevant field - Applied research experience with a track record of solving complex technical problems and delivering results - Experience with LLMs, reasoning systems, and agentic AI, including architecture design, training, fine-tuning, and evaluation - Experience building or evaluating agentic systems (planning, tool use, retrieval, verification) - Publication record at ML or computational biology venues - PhD in Machine Learning, Computer Science, Computational Biology, or related field, or MS with equivalent applied research experience - Demonstrated ability to apply model customization techniques (fine-tuning, RLHF, retrieval augmentation, domain adaptation) to specific downstream applications - Excellent programming skills in Python and deep learning frameworks (PyTorch, JAX), with a modern development practice that embraces AI-assisted coding and iteration - Experience designing agent evaluations or benchmarks for scientific or high-stakes domains - Experience with clinical data standards (e.g., SDTM/ADaM) or regulatory science - Experience with graph neural networks or causal inference - Domain experience in life sciences or computational biology (protein engineering, antibody design, genomics, or clinical data) - Experience translating research into products or services that others use - Experience taking 0-to-1 capabilities from initial research through first customer delivery Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit amazon.jobs for more information. If the country/region you’re applying in isn’t listed, please contact your Recruiting Partner. The base salary range for this position is listed below. Your Amazon package will include sign-on payments and restricted stock units (RSUs). Final compensation will be determined based on factors including experience, qualifications, and location. Amazon also offers comprehensive benefits including health insurance (medical, dental, vision, prescription, Basic Life & AD&D insurance and option for Supplemental life plans, EAP, Mental Health Support, Medical Advice Line, Flexible Spending Accounts, Adoption and Surrogacy Reimbursement coverage), 401(k) matching, paid time off, and parental leave. Learn more about our benefits at amazon.jobs . USA, WA, Seattle - 142,800.00 - 193,200.00 USD annually

Requirements

Must-haves

We value scientific rigor encourage publication and support conference participation. If you want to do research that ships this is the team.
How do you build LLM-based agentic systems that correctly reason over clinical protocols regulatory standards and complex multi-step operational workflows?
How do you evaluate agent reliability and faithfulness rigorously enough to trust in high-stakes clinical settings?
How do you develop model customization methods (fine-tuning retrieval augmentation domain adaptation) that let customers get strong results from foundation models on their own data?
Key job responsibilities
Design train fine-tune and evaluate LLM-based agentic systems that reason over clinical protocols regulatory standards and operational workflows
Build rigorous evaluation harnesses and benchmarks to measure agent reliability faithfulness and failure modes in high-stakes domains
Develop model customization methods (fine-tuning RLHF retrieval augmentation domain adaptation) that help customers get better outputs on their own data with less effort
Contribute to graph-based and causal modeling approaches for clinical trial operations
Partner with Life Sciences domain experts product and engineering to translate scientific challenges into shipped capabilities
Own experiments end to end: problem framing implementation evaluation iteration and hand-off to production
Publish at top-tier venues where the work supports it
Contribute to drug discovery efforts (protein engineering antibody design) as opportunities arise
A day in the life
Design and run an experiment to validate a new agentic reasoning or fine-tuning method then ship it as a capability customers can use
Diagnose why a model is failing on a new class of inputs and implement a fix to unblock a delivery milestone
Build or extend an evaluation benchmark to measure how faithfully an agent reasons over clinical logic
Meet with domain experts to scope what the next model release needs to do
Review results with a senior scientist sharpen the approach and get it over the finish line
Prototype a new idea that could become the next capability in the product
About the team
Master's degree or above in a relevant field
Applied research experience with a track record of solving complex technical problems and delivering results
Experience with LLMs, reasoning systems, and agentic AI, including architecture design, training, fine-tuning, and evaluation

Nice-to-haves

None flagged.

Application prep

Use the role’s language and application details while tailoring your materials.

Keywords to mirror

awsairestllmmlmachine learningpython

Platform: amazon
Effort: medium

Benefits

Benefits detected in the listing.

Health Insurance

Dental

Vision

401(K)

Paid Time Off

Parental Leave