Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.
Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).
Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.
We are seeking an Executive Director, U.S. HCP Marketing for Rezdiffra, to shape and actualize the HCP marketing strategy for Rezdiffra and the broader MASH therapeutic category. This role is a high-visibility role for a leader who can operate can shape brand and content strategy while being comfortable with a roll your sleeves up approach in tactical development and execution. This individual will need to embrace a business-owner mentality needed to be successful at a rapidly growing company fueled by the growth of a blockbuster brand. This individual will lead all HCP-facing marketing efforts, including personal and non-personal promotion, peer to peer education through speakers bureau and advisory boards, congress presence execution, and content creation and evolution for field teams. We are seeking a highly collaborative leader who will partner closely with Sales, Commercial Strategy and Operations, Market Access, Medical Affairs, Regulatory, and Legal to ensure compliant, insight-driven, and commercially effective execution.
This role is ideal for a marketing leader who thrives in a fast-paced environment in an organization that is continuously evolving to leverage governance to formalize decision-making and ways of working. The ideal candidate is a strong communicator/presenter and is comfortable transitioning from being a strategist to a doer, who ultimately relishes an opportunity to make a meaningful impact on a successful and highly visible launch brand.
Key Responsibilities
Strategic Leadership
Own the HCP marketing strategy and contribute to the development of the annual global brand plan for Rezdiffra, aligning tactics to lifecycle stage, competitive dynamics, and portfolio priorities.
Translate market research, prescriber analytics, and customer feedback into a clear, differentiated brand positioning and messaging framework for HCP audiences.
Anticipate and plan for competitive threats (new entrants, label expansions) and adjust HCP strategy accordingly.
Campaign & Content Development
Lead development of core and derivative promotional tools and continue to evolve promotional claims beyond label by leveraging FDA’s CFL guidance.
Oversee non-personal promotion (NPP) strategy across peer-to-peer channels, paid media, and programmatic/digital channels targeting HCPs.
Ensure all materials are scientifically accurate, on-label, and approved through Promotional Review Committee (PRC) composed of Medical, Legal, and Regulatory.
KOL & Congress Strategy
Develop and manage KOL engagement strategy in partnership with Thought Leader Liaison team, Medical Affairs, and Sales including oversight of advisory boards and promotional speaker bureau.
Own planning and execution for major medical congresses and conferences (booth strategy, product theaters, print and digital sponsorships).
Sales Enablement
Serve as the primary marketing partner to Sales Leadership; ensure each field team is equipped with compelling, compliant tools and messaging.
Partner closely with Commercial training and development for implementation of new tools and messaging during and outside of planned national and regional sales meetings
Omni-channel/non-personal promotion
Lead the transformation from traditional campaign-based marketing to AI-driven, dynamic engagement models by championing the use of customer-centric analytics to deliver personalized customer approaches across channels.
Partner with Commercial Strategy and Analytics and appropriate external vendors to build and monitor performance dashboards (Rx trends, NPS, share of voice, digital engagement).
Monitor marketing mix effectiveness and use insights to optimize strategies and tactics.
Cross-Functional Collaboration
Collaborate with Patient Marketing counterparts to ensure a unified HCP-to-patient journey.
Cultivate strong working partnerships with Sales, Thought Leader Liaison, Commercial Strategy and Analytics, Market Access and Patient Services to ensure a cohesive brand story
Work closely with Regulatory and Legal/Compliance to navigate promotional review and ensure adherence to PhRMA Code, FDA regulations (OPDP), and company SOPs.
Team Leadership & Operations
Hire, coach, and develop high-performing HCP marketing team
Own HCP marketing budget tracking, forecasting, and reconciliation
Manage relationships with external agencies (creative, media, medical communications) to ensure high-quality, on-time, on-budget deliverables.
Prepare regular reports for commercial and executive leadership team on progress, challenges, and recommendations.
Required Qualifications
Bachelor s degree required; MBA or advanced degree preferred.
18 years of pharmaceutical/biotech marketing experience, with 10 years in HCP-facing brand marketing roles of increasing responsibility with a majority of experience on a specialty brand. Experience in liver and/or a cardiometabolic therapy preferred.
Proven experience marketing a blockbuster or high-growth/high-potential specialty product.
Demonstrated success building and actualizing HCP marketing strategy within constraints and processes mandated by a Subpart H (conditional approval)
Demonstrated experience as a people leader managing and leading Marketing professionals.
Excellent cross-functional collaboration skills, particularly with Sales, Thought Leader Liaisons, Medical Affairs, Market Access, and Legal/Regulatory.
Ability to distill complex information into essential knowledge and persuasively present it to all levels of management.
Strong interpersonal skills, including the ability to lead, identify and resolve conflict, and drive consensus among individuals from a variety of viewpoints and disciplines.
Role requires up to 30% US travel
Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $300,282 - $345,264 per year. We comply with all applicable minimum wage laws.
All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.
Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.
We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact HR madrigalpharma.com.
Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.
Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.
Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.
Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.
Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to HR madrigalpharma.com .